Conclusion and References

Conclusion

Healing trajectories are a useful tool for evaluating “time to healing”, especially with the utilization of clinical data (Payne et al, 2011). Wound healing trajectories are useful for both acute wounds and chronic wounds, including venous stasis ulcers (Kantor and Margolis, 2000; Hill et al, 2004; Steed et al, 2006; Cardinal et al, 2009) and diabetic foot ulcers (Sheehan et al, 2003; Cardinal et al, 2008). The value of wound trajectory utilization for pressure injuries has also been proven (Hill et al, 1999; Payne et al, 2001; Payne et al, 2011). Efficient clinical trial protocol designs should include wound healing trajectories.

Key Learning Points

  1. An accurate wound diagnosis is an important first step in determining the ability of the wound to heal
  2. Chronic wounds fall into one of three categories: healable; maintenance and nonhealable
  3. Wound status can change and should be regularly monitored
  4. Healing trajectory is a more reliable wound tracker than single point wound area measurement

 

REFERENCES

Bharara, M., Schoess, J., Nouvong, A., & Armstrong, D. G. (2010). Wound inflammatory index: a “proof of concept” study to assess wound healing trajectory. Journal of diabetes science and technology4(4), 773–779.

Cardinal, M., Eisenbud, D.E., Phillips, T. and Harding, K. (2008), Early healing rates and wound area measurements are reliable predictors of later complete wound closure. Wound Repair and Regeneration, 16: 19-22.

Cardinal, M., Phillips, T., Eisenbud, D.E. et al. Nonlinear modeling of venous leg ulcer healing rates. BMC Dermatol 9, 2 (2009).

Carrel A, Hartmann A. The relation between the size of a wound and the rate of its cicatrization. J Exp Med 1916;24:429–450.

Cherry GW, Ryan TJ, Hoffman D. Tissue repair in patients with chronic venous leg ulcers treated with prezatide copper acetate gel and standard compression therapy [abstract]. Presented at the Symposium on Advanced Wound Care and Medical Research Forum on Wound Repair; April 18–22, 1998; Miami, FL. Abstract E7.

Despatis, M., Shapera, L., Parslow, N. Woo, K. (2008) Complex Wounds WCC 8(2):24-25.

Du Nouy PL. Mathematical expression of the curve representing cicatrization. J Exp Med 1916;24:451–460.

Feldman D (2018) Use of Imaging Techniques to Assess Skin Wound Healing for Tissue Engineering and Regenerative Medicine. Int J Biol Instrum 1:002.

FDA Wound Healing Clinical Focus Group. Guidance for industry: chronic cutaneous ulcer and burn wounds—developing products for treatment. Wound Rep Reg. 2001;9:258-68.

Gilman TH. Parameter for measurement of wound closure. Wounds 1990;2:95–101.

Han, G., & Ceilley, R. (2017). Chronic Wound Healing: A Review of Current Management and Treatments. Advances in therapy34(3), 599–610.

Hill DP, Poore S, Wilson J, Robson MC, Cherry GW. Initial healing rates of venous ulcers: are they useful as predictive of healing? Am J Surg 2004;188(1A Suppl):22—5.

Hill DP, Payne WG, Robson MC. Wound trajectories to determine pressure ulcer treatment efficacy. Wound Rep Reg 1999;7:A256.

Hokanson JA, Hayward PG, Carney DH. A mathematical model for the analysis of experimental wound healing data. Wounds 1991;3:213–220.

Kantor J, Margolis DJ. A multicentre study of percentage change in venous leg ulcer area as a prognostic index of healing at 24 weeks. Br J Dermatol 2000;142:960–964.

Laporte M, Keller HH, Payette H, et al. Validity and reliability of the new Canadian Nutrition Screening Tool in the ‘real-world’ hospital setting. Eur J Clin Nutr 2015;69(5):558-64.

Margolis DJ, Gross EA, Wood CR, Lazurus GS. Planimetric rate of healing in venous ulcers of the leg treated with pressure bandage and hydrocolloid dressing. J Am Acad Dermatol 1993;28:418—21.

Margolis DJ, Berlin JA, Strom BL. Which venous leg ulcers will heal with limb compression bandages? Am J Med 2000;109:15–19.

Margolis DJ, Gross EA, Wood CR, Lazarus GS. Planimetric rate of healing in venous ulcers of the leg treated with pressure bandage and hydrocolloid dressing. J Am Acad Dermatol 1993;28:418–421.

McQuilling, JP,  Carter, MJ,  Fulton, JA, et al.  A prospective clinical trial evaluating changes in the wound microenvironment in patients with chronic venous leg ulcers treated with a hypothermically stored amniotic membrane. Int Wound J.  2021; 1– 12.

Norris R and Chapman-Jones D (2015) Healing trajectories as an indicator of clinical outcomes in patients with venous leg ulcers. Wounds UK, Vol 11 (4): 68-73.

Payne WG, Ochs DE, Meltzer DD, et al. Long-term outcome study of growth-factor treated pressure ulcers. Am J Surg. 2001;181:81-6.

Payne WG, Bhalla R, Hill DP, Pierpont YN, Robson MC. Wound healing trajectories to determine pressure ulcer treatment efficacy. Eplasty. 2011;11:e1. Published 2011 Jan 10.

Phillips TJ, Machado F, Trout R, Porter J, Olin J, Falanga V. Prognostic indicators in venous ulcers. J Am Acad Dermatol2000;43:627–30.

Polansky M, Van Rijswijk L. Utilizing survival analysis techniques in chronic wound healing studies. Wounds 1994;6:150—8.

Prince S and Dodds SR. (2006). Use of ulcer size and initial responses to treatment to predict the healing time of leg ulcers, Journal of Wound Care. 15:7, 299-303

Orsted Heather L., Keast David H., Kuhnke Janet, Armstrong Pamela et al. ( 2010). Best Practice Recommendations for the Prevention and Management of Open Surgical Wounds. 1, s.l. : Wound Care Canada, Vol. 8.

Queen D. (2019). Artificial intelligence and machine learning in wound care-The wounded machine!. International wound journal16(2), 311.

Robson MC, Steed DL, Franz MG. Wound healing: biologic features and approaches to maximize healing trajectories. Curr Prob Surg. 2001;38:61-140.

Robson MC, Hill DP,Woodske ME, Steed DL.Wound healing trajectories as predictors of effectiveness of therapeutic agents. Arch Surg. 2000;135:773-7.

Sheehan  P, Jones  P, Caselli  A, Giurini  JM, Veves  A. Percent change in wound area of diabetic foot ulcers over a 4-week period is a robust predictor of complete healing in a 12-week prospective trial. Diabetes care.  2003 Jun1;26(6):1879–82

Sibbald RG, Elliott JA, Persaud-Jaimangal R, Goodman L, Armstrong DG, Harley C, Coelho S, Xi N, Evans R, Mayer DO, Zhao X, Heil J, Kotru B, Delmore B, LeBlanc K, Ayello EA, Smart H, Tariq G, Alavi A, Somayaji R. Wound Bed Preparation 2021. Adv Skin Wound Care. 2021 Apr 1;34(4):183-195.

Sibbald RG, Goodman L, Woo KY, Krasner DL, Smart H, Gulnaz T, Ayello EA, Burrell RE, Keast DH, Mayer D, Norton L. Special considerations in wound bed preparation 2011: An update. In: Krasner DL, Rodeheaver GT, Sibbald RG, Woo KY, eds. Chronic Wound Care: A Clinical Source Book for Healthcare Professionals. 5th ed. Vol 1. Malvern, PA: HMP Communications, 2012: 173-197.

Snowden JM. Wound closure: an analysis of the relative contributions of contraction and epithelialization. J Surg Res 1984;37:453–463.

Steed DL, Hill DP,Woodske ME, Payne WG, Robson MC.Wound-healing trajectories as outcome measures of venous stasis ulcer treatment. Int Wound J. 2006;3:40-47.

Tallman P, Muscare E, Carson P, Eaglstein WH, Falanga V. Initial rate of healing predicts complete healing of venous ulcers. Arch Dermatol 1997;133:1231–1234.

Tranquillo RT, Murray JD. Mechanistic model of wound contraction. J Surg Res 1993;55:233–247.

Wang, S. C., Anderson, J., Evans, R., Woo, K., Beland, B., Sasseville, D., & Moreau, L. (2017). Point-of-care wound visioning technology: Reproducibility and accuracy of a wound measurement app. PloS one12(8), e0183139.

License

Share This Book