9.5 Test your knowledge!

1. Nevi’s can spontaneously turn into melanomas?

1. True
2. False

Mutations in which of the following genes is needed for cancer initiation in a nevi. (Select all that apply)

1. BRAF
2. BRAC1
3. CCNO
4. P53
5. MDM2

Select the incorrect answer.

1. Zebrafish are used to model cancer as they are easy to breed
2. Nevi is a birthmark or mole.
3. SETDB1 is an upstream transcriptional regulator of BRAFv600E
4. Crestin is turned on in melanoma initiation.

Which of the following is not future directions for melanoma research?

1. Excision of the melanoma site
2. Therapeutic cream to switch off expression of certain genes
3. Detection of markers of NPC through new technologies

Select the most correct answer regarding why zebrafish are used as model organisms?

1. 1. 1. 1. 1. They are cheap
            2. They are easy to breed
            3. Genetic similarity with humans
            4. Derived from the same lineage as humans
            5. They have vertebrae

1. i, ii, iv,
2. ii,iii,iv, v
3. I,ii,iiii, v
4. All of the above
5. None of the above