17 Table of Contents

6.1  – Introduction by Cecillia Tang 

• 6.1.1. Overview of fasting
• 6.1.2. Overview of Fasting Mimicking Diet (FMD)
• 6.1.3. Experimental Evidence
  • Benefits of FMD on health

6.2 – FMD Methods Used in Experimental Research by Monica Tu Do

• Mice
  • Study by Brandhorst et al.
  • Micro-CT Scans
• Humans
  • Study by Brandhorst et al.
  • DEXA/DXA Scans

6.3 – Effects of FMD on aged mice by Cherry Woo

• 6.3.1.  Changes in the bodyweight after FMD
• 6.3.2. Blood glucose, serum insulin, and IGF-1 level, organ size
• 6.3.3. Regeneration of the liver cells and skeletal muscle cells
• 6.3.4. Cancer incidence

6.4 – Effects of FMD on humans by Cherry Woo

• 6.4.1. Glucose level, IGF-1 level, and body weight
• 6.4.2. Inflammation and Cardiovascular disease risk factor

6.5 – Key Takeaways from the Fasting Mimicking Diet by Zhiyin Li

• Ket takeaways for mice
• Key takeaways for humans
• Pros and Cons

6.6. – The Future of FMD by Thahmina Rahman

• 6.6.1. Limitations – Can FMD become a universal treatment?
  • Maintaining the benefits of FMD
  • FMD and Age
  • [Aside: Are social factors worth considering?]
• 6.6.2. Need for Clinical Trials and Possible Mechanisms
  • Possible Mechanisms
    • Example 1: FMD and Diabetes
    • Example 2: FMD and Multiple Sclerosis
• 6.6.3. Closing Remarks