Gladys’ Health Part A: Chronic Obstructive Pulmonary Disease (COPD)

Gladys was diagnosed with Gold B COPD in 1999.

2010 – Cognitive changes – diagnosed with Alzheimer’s disease

2015 – Oxygen therapy for COPD

2018 – Health and wellbeing deteriorated – placed in LTC facility

2019 – Dies due to complications of Alzheimer’s disease

Gladys’ Symptoms

Gladys had a hard time managing her smoking habit. She began to experience the following symptoms:

  • Shortness of breath while doing everyday activities
  • Chronic cough
  • Producing a lot of mucus
  • Fatigue

Respiratory Zone

This image shows the bronchioles and alveolar sacs in the lungs and depicts the exchange of oxygenated and deoxygenated blood in the pulmonary blood vessels.
CC-BY-3.0 https://openstax.org/books/anatomy-and-physiology/pages/22-1-organs-and-structures-of-the-respiratory-system

Airway Obstruction in COPD

Demonstrates how Chronic Obstructive Pulmonary Disorder (COPD) affects breathing by decreasing the air flow and gas exchange in the lungs.
CC Public Domain https://commons.wikimedia.org/wiki/File:How_Does_COPD_Affect_Breathing%3F_(49086385167).jpg

COPD Diagnosis

Spirometry measures the amount of air you can inhale and exhale, and whether your lungs deliver enough oxygen to your blood. During the most common test, called spirometry, you blow into a large tube connected to a small machine to measure how much air your lungs can hold and how fast you can blow the air out of your lungs.

Other pulmonary function tests include:

  • History & Risk factors
  • Physical exam
  • Assess severity
  • Pulse oximetry
  • Exercise Testing
  • Complete Blood Count
  • Arterial Blood Gas

Gladys’s Pulmonary Function Test Results

  • FEV₁ – the forced expiratory volume in 1 second
  • FVC – the forced vital capacity
  • The FEV₁/FVC ratio is used to define obstructive defect and used to diagnose the disease progression.

FEV₁+FVC=FEV₁/FVC

  • Your FEV₁ is influenced by other factors including age, sex, height, and ethnicity.
Illustration of Spirometry and Respiratory Volumes.
CC-BY-3.0 https://upload.wikimedia.org/wikipedia/commons/thumb/9/93/2317_Spirometry_and_Respiratory_Volumes.jpg/640px-2317_Spirometry_and_Respiratory_Volumes.jpg

Risk Factors of COPD Among Women

  • 3.17 million deaths (5% of all global deaths) were caused by COPD in 2015
  • WHO reports a prevalence of 251 million cases of COPD in 2016
  • COPD diagnoses and mortality are greater among men compared to women
  • But in developed countries like Canada, COPD diagnoses and mortality is almost equal in men and women

Most common risk factors:

  • Smoking
  • Exposure to secondhand smoke
  • Air pollution
  • Occupational dust and fumes

Influence of sex on COPD involves several factors:

  • Differential susceptibility to the effects of tobacco
  • Anatomic, hormonal, and behavioural differences
  • Differential response to therapy

Which of these risks are relevant to Gladys’ case?

Metabolism

  • Step 1: Glycolysis
  • Step 2: Transformation of pyruvate to acetyl CoA
  • Step 3: Citric Acid Cycle
  • Step 4: Oxidative phosphorylation
Depicts the various metabolic pathways part of a cell.
CC BY SA 3.0 https://commons.wikimedia.org/wiki/File:Metabolism1.png

The process of changing food to fuel in the body is called metabolism.

  • Oxygen and food are the raw materials of the process.
  • Energy and carbon dioxide are the finished products.
  • Carbon dioxide is a waste product that is exhaled.
  • Metabolism of carbohydrates produces the most carbon dioxide for the amount of oxygen used.
  • Metabolism of fat produces the least.
  • For some COPD patients, eating a diet with fewer carbohydrates and more fat helps them breathe easier.

Treatment for Gladys

Gladys was referred to a respiratory specialist and enrolled into a smoking cessation program, but was unable to quit.

To facilitate an active lifestyle and exercise was referred to a pulmonary rehabilitation program that included self-management education.

She was provided with the recommended medications that included inhalers and vaccinations and had regular follow-up appointments with her specialist.

Gladys’ new recommended diet

  • Vitamins and minerals:
    • Steroids may increase your need for calcium
    • Calcium carbonate or calcium citrate with vitamin D
    • Sodium may cause edema and may increase blood pressure
    • Drink plenty of water-keeps you hydrated and keeps the mucus thin
  • Rest before eating.
  • Eat more food early in the day if you are usually too tired to eat later on.
  • Avoid foods that cause gas or bloating. Tends to make breathing more difficult.
  • Eat 4 to 6 small meals a day. Enables the diaphragm to move freely and lets the lungs fill and empty more easily.
  • Drinking fluids with meals may make you feel too full. Drink an hour before or after meals.
  • Consider adding nutritional supplements at night to avoid feeling full during the day.

Physical Activity and COPD

Moderate exercise has benefits:

Physical benefits

  • The body’s use of oxygen
  • Energy levels
  • Cardiovascular fitness
  • Muscle strength
  • Shortness of breath (SOB)

Emotional & Mental Benefits

  • Anxiety
  • Stress & depression
  • Sleep
  • Self-esteem

Exercises help blood circulate, help your heart send oxygen to your body, and strengthen your respiratory muscles.

Types of Exercises for COPD

Pulmonary Rehabilitation consists of education and exercise classes that teach about lungs, the disease, and how to exercise and be more active with less SOB.

Examples include:

  • Stretching
  • Aerobic
  • Resistance

Self-management: COPD and Emotional Health

If feelings of sadness, fear and worry start to affect ability to keep up with normal activities and life enjoyment, they may be symptoms of anxiety and depression

Managing anxiety and depression can increase ability to stick with treatment, improve physical health, and reduce medical costs

Things to do:

  • Talk to healthcare team
  • Self care
  • Connect with others who understand

Treatment for Gladys continued

In 2015,Gladys was able to quit smoking, but the disease progressed to stage GOLD C COPD.

She was prescribed long-term oxygen therapy and oral medications.

Shows a woman holding an inhaler on the left with the 3 types of bronchioles shown in a cycle, Normal bronchiole at the top, Constricted Bronchioles on the right, and Medication dilates constricted bronchioles at the bottom.
CC BY-SA 4.0 https://upload.wikimedia.org/wikipedia/commons/thumb/e/e3/Bronchodilators.png/640px-Bronchodilators.png

Gladys’ Medications

Bronchodilators

  • Open airway by Relaxing the muscles around the airways
  • Short-acting bronchodilators can be either SABAs (short-acting beta-agonists) or SAMAs (short-acting muscarinic antagonists). Often called “rescue medications” because they act quickly
  • Long-acting bronchodilators can be either LABAs (long-acting beta2 agonists) or LAMAs (long-acting muscarinic antagonists). Often called “preventative or maintenance medications”

Inhaled Corticosteroids (ICS)

  • Reduces swelling and mucus production
  • Long-term use of steroids have may have serious side effects

License

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Multi-Course Case Studies in Health Sciences (Version 2) Copyright © 2021 by Laura Banks; Elita Partosoedarso; Manon Lemonde; Robert Balogh; Adam Cole; Mika Nonoyama; Otto Sanchez; Sarah West; Sarah Stokes; Syed Qadri; Robin Kay; Mary Chiu; and Lynn Zhu is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License, except where otherwise noted.

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