Update & Change Log

Sept 4, 2025

• Updated 1.2 number of genes in the human genome (changed from 20,000 to 80,000 per GENCODE v.49)

July 21, 2025

• Updated Print PDF and Digital PDF with July 16 changes.

July 16, 2025

• Updated 8.4 ACMG Secondary Findings Guidelines from v3.2 (2023) to v3.3 (2025) in text and reference list.
• Updated 8.5 ACMG Secondary Findings Guidelines from v3.2 (2023) to v3.3 (2025) in resource list.

January 10, 2024

• First publication – view this version of the book in Print PDF or Digital PDF versions