Learning Objectives

This information is learning material for VETM*4490 Systems Pathology, a third-year course for DVM students that covers anatomic pathology of the respiratory system of domestic mammals. The current web-based version is here: https://ecampusontario.pressbooks.pub/pathologyoftherespiratorysystem/     Please report errors of content or formatting to jcaswell@uoguelph.ca

general learning objectives

  1. Discuss the differences between bronchopneumonia, interstitial lung disease, airway disease, and embolic pneumonia; with regard to cause, route of infection, pathogenesis, and gross and histologic lesions. List causes of each of these types of pneumonia in dogs, cats, cattle, swine, sheep, goats, and horses.
  2. By examining specimens or photos of lung lesions from the species of animals listed above, classify the type of pneumonia (bronchopneumonia, interstitial pneumonia, airway disease, and embolic pneumonia), formulate a list of differential diagnoses, and list which additional tests would be useful to make a definitive diagnosis.
  3. Identify and interpret cytological findings in transtracheal washes, bronchoalveolar lavages, and pulmonary aspirates with respect to the underlying disease processes, including infectious, allergic, and neoplastic diseases of the lung.
  4. Describe the sequelae of injury to bronchiolar or alveolar epithelium, and predict the functional and clinical changes that result from these lesions.
  5. Discuss the cause, pathogenesis, morphology, and functional and clinical significance of the following conditions: atelectasis, bronchiectasis, bronchiolitis obliterans, emphysema, hydrothorax, pneumothorax, pulmonary edema, pulmonary hemorrhage, sequestrum.
  6. Describe how the lung is normally defended against bacterial infection, and list several causes whereby these defences are impaired.

Specific diseases

In the following tables, diseases are grouped by priority for the course. Please recognize that even “Course priority #3” diseases have huge importance in some circumstances or geographic regions. Expectations for the course are:

  1. Course priority #1 diseases: Discuss their importance, causes, pathogenesis, clinical-epidemiologic presentation, gross and histologic lesions, and diagnostic tests.
  2. Course priority #2 diseases: Describe their cause, gross lesions, type of pneumonia, and diagnostic tests (where appropriate).
  3. Course priority #3 diseases: List their cause, importance, and type of pneumonia.
Course priority #1 Course priority #2 Course priority #3
Dogs
  • Blastomycosis
  • Pulmonary neoplasia
  • Bacterial pneumonia
  • Nasal aspergillosis
  • Nasal carcinoma
  • ARDS
  • Eosinophilic lung disease
  • Pulmonary embolism
  • Pyothorax
  • Herpesvirus
  • Kennel cough
  • Tracheal collapse
  • Oslerus oslerii
  • Crenosoma vulpis
  • Canine distemper
Cats
  • Viral: herpes, calicivirus
  • Bacterial pneumonia
  • Pulmonary neoplasia
  • FIP
  • Paragonimus
  • Aleurostrongylus
  • Empyema
  • Cryptococcosis
  • Bordetella
  • Mycoplasma felis
  • Toxoplasmosis
  • Idiopathic pulmonary fibrosis
Horses
  • Rhodococcus equi
  • Strangles/Streptococcus equi
  • Equine influenza
  • Equine viral rhinotracheitis
  • Asthma (heaves)
  • Interstitial pneumonia of foals
  • Guttural pouch mycosis
  • Exercise-induced pulmonary hemorrhage
  • Pleuropneumonia
  • Equine rhinoviruses
  • Equine adenovirus
  • Dictyocaulus arnfieldi
  • Pneumocystis carinii
Cattle
  • Pneumonic pasteurellosis (Mannheimia, Bibersteinia, Histophilus, Pasteurella)
  • Mycoplasma bovis
  • Bovine respiratory syncytial virus
  • Infectious bovine rhinotracheitis
  • 3-MI toxicity
  • Aspiration pneumonia
  • Histophilus somni pleuritis
  • Parainfluenza, coronavirus
  • Embolic pneumonia
  • Dictyocaulus
  • Tuberculosis
  • Interstitial pneumonia of feedlot cattle
  • Ascaris suum larval migration
  • Contagious bovine pleuropneumonia
Sheep and goats
  • Bacterial pneumonia
  • Maedi-visna/ovine progressive pneumonia
  • Muellerius capillaris
  • Pasteurellosis: pneumonic and septicemic forms
  • Respiratory syncytial viruses
  • Mycoplasma spp.
  • Oestrus ovis
  • Transmissible nasal carcinoma
  • Ovine pulmonary adenocarcinoma
  • Peste des petits ruminants
Swine
  • Porcine reproductive and respiratory syndrome
  • Mycoplasma hyopneumoniae
  • Swine influenza
  • Actinobacillus pleuropnuemoniae
  • Streptococcus suis
  • Porcine circovirus/PMWS
  • Atrophic rhinitis
  • Haemophilus parasuis
  • Pseudorabies
  • Porcine respiratory coronavirus
  • Metastrongylus
  • Inclusion body rhinitis
  • Actinobacillus suis

References

  1. Pathologic Basis of Veterinary Disease. Zachary JF (ed). At a level suitable for the DVM program.
  2. Pathology of Domestic Animals. Maxie MGM (ed). For reference only.

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