63 5.9: Aggregation of Mitochondrial Nucleoids and mtDNA Damage
Quant-iT PicoGreen dye can be used to visualise mtDNA damage as a result of increased ROS production. Both treatment groups express brighter fluorescence as a result of potential nuclear envelope damage and therefore reveal increased mtDNA nucleoid aggregation (Zahedi et al., 2019).
Key Takeaways
- Both treatment groups cause increased nuclear envelope damage
- This occurs due to increased nucleoid aggregation and mtDNA damage