5 1.1 Cells Used for Research
A549 Cells
The A549 cell line was established by D.J. Giard and his group in 1972.[1] The cells were developed through an explant culture of cancerous lung tissue from a 58-year old Caucasian male. This cell line has become the standard for non-small cell lung cancer research.[2]
A549 cells are adenocarcinomic human alveolar basal epithelial cells and have been used to study lungs, lung cancer, and develop therapies in vitro and in vivo.[3][4]This cell line has been involved in the development of drugs such as paclitaxel, docetaxel, and bevacizumab.[5]
- A549 Cell Line: Cell Culture and Transfection Protocol. (n.d.). Retrieved December 1, 2019, from http://www.a549.com/ ↵
- A549 - A Model for Non-Small Cell Lung Cancer - MI Bioresearch. (n.d.). Retrieved November 12, 2019, from https://www.mibioresearch.com/knowledge-center/model-spotlight-a549-a-model-for-non-small-cell-lung-cancer/ ↵
- Giard, D. J., Aaronson, S. A., Todaro, G. J., Arnstein, P., Kersey, J. H., Dosik, H., & Parks, W. P. (1973). In Vitro Cultivation of Human Tumors: Establishment of Cell Lines Derived From a Series of Solid Tumors2. JNCI: Journal of the National Cancer Institute, 51(5), 1417–1423. https://doi.org/10.1093/jnci/51.5.1417 ↵
- Foster, K. A., Oster, C. G., Mayer, M. M., Avery, M. L., & Audus, K. L. (1998). Characterization of the A549 Cell Line as a Type II Pulmonary Epithelial Cell Model for Drug Metabolism. ↵
- A549 - A Model for Non-Small Cell Lung Cancer - MI Bioresearch. (n.d.). Retrieved November 12, 2019, from https://www.mibioresearch.com/knowledge-center/model-spotlight-a549-a-model-for-non-small-cell-lung-cancer/ ↵