40 Chapter Overview
Learning Objectives
After reading this chapter, you will be able to
- Explain what happens during myocardial infarction
- Identify the processes that occur post-myocardial infarction
- Describe the relationship between the extracellular matrix and myocardial infarction
- Describe the current treatments and their limitations
- Appreciate the emerging use of injectable rHC for myocardial infarction treatment
- Understand the efficacy and limitations of rHC in MI treatment
4.2 Introduction
Myocardial Infarction
The Extracellular Matrix and The Heart
Current Literature
4.3 Current Treatments
Introduction
Pharmacological
Surgeries
Growth factors
Cell-based therapies
Biomaterials
4.4 The Use of rHC in MI
Experimental design
Post-MI Cardiac Function and Morphology
Post-MI Vascularity and cardiomyocyte preservation
Mononuclear cell recruitment
In vitro assessment of rHC matrices
4.5 Efficacy of rHC in MI
Importance of findings
Current Literature
Limitations