Drug Discovery To Market

Topic – 6-mercaptopurine as inhibitor used in the treatment of leukemia

Key Takeaway: “The answer from ChatGPT to the highly specific query was generalized and included fictional information. Additionally, the references provided were inaccurate based on validation conducted on 24 September 2023 which revealed that the drug 6-mercaptopurine used in the treatment of leukemia, is an example of an allosteric inhibition. This was confirmed by Graham L. Patrick – An Introduction to the Medicinal Chemistry-Oxford University Press (2013) textbook. In addition, the Google search for the results showed zero results as shown below:”

AI improves through reinforcement learning by adapting its performance based on feedback, such as rewards or penalties. With the right prompts and ongoing input, it refines its responses to meet user needs, delivering customized and relevant information.

Figure: The reference found in Medicinal Chemistry-Oxford University Press (2013) textbook for validation.

Figure: The reference search on Google Scholar provided by Chat GPT for validation.

Chat-GPT Prompt: Act as my assignment assistant. I am a graduate student at the University of Windsor studying Master’s in Medical Biotechnology. I need your help in doing my assignment in the Drug from Discovery to Market course. I am struggling with this question. The drug 6-mercaptopurine used in the treatment of leukemia is an example of Inhibition. Also, provide relevant references in the APA format 7th edition and doi.

Chat GPT Response:

I’d be happy to assist you with your assignment.

**6-Mercaptopurine** is an important drug used in leukemia treatment. It is an example of **enzyme inhibition**, specifically **competitive inhibition**.

Here’s an explanation:

**Competitive inhibition** occurs when a molecule closely resembles the substrate and competes with the substrate for binding to the enzyme’s active site. In the case of 6-mercaptopurine, it is a structural analog of adenine and guanine, which are components of DNA and RNA. 6-mercaptopurine competes with these natural substrates for binding to enzymes involved in DNA and RNA synthesis. By doing so, it inhibits the synthesis of DNA and RNA in rapidly dividing leukemia cells, which is essential for their growth. This inhibition helps to slow down or stop the uncontrolled growth of leukemia cells.

**References** (APA 7th Edition Style):

– Jones, A. B., & Smith, C. D. (2021). Mechanisms of Action of 6-Mercaptopurine and Its Clinical Applications in Leukemia Treatment. Journal of Medical Chemistry, 45(7), 1234-1245. https://doi.org/10.12345/jmc.2021.45.7.1234

Please note that the provided reference is fictional and for illustrative purposes only. When writing your assignment, it’s important to consult actual, peer-reviewed sources to support your explanation. Feel free to ask if you have any further questions or need more assistance with your assignment.

Last Updated November 20, 2024

Artificial Intelligence in Higher Education © 2025 by Ayah Malouhi, Tranum Kaur, Tasfia Tahiat is licensed under CC BY-SA 4.0